6-Thioguanine (6 TG) Resistant Mutation, Chromosomal Aberrations and Sister Chromatid Exchanges (SCE's) in V 79 Cells

I. Induced by Safrole

Abstract

Safrole, a naturally occurring substance in spices, was screened for its genotoxic potentialities in V79 cell line system. It showed weak mutagenic and SCE's enhancing effects. However, the magnitude of aberrant metephases was considerably high. Chromosomal abnormalities were: gap, break, exchange figures, dicentric chromosome types. The possible genetic hazards have been discussed.