Sister Chromatid Exchange and Chromosome Aberrations Analyses for a New 8-aminoquinoline Derivative After in vivo Exposure in Mice

抄録

A new antimalarial compound 8-aminoquinoline derivative, N¹-(3-acetyl-4-5-dihydro-2-furanyl)-N⁴-(6-methoxy-8-quinolinyl), 1, 4-pentanediamine, Central Drug Research Institute code No. 80/53, has been evaluated for the in vivo genotoxicity assay as measured by the sister chromatid exchange and chromosome aberrations in bone marrow cells of mice. The trend tests for the evidence of dose response effects for both SCE and CA were negative. No significant increase in SCE or CA were observed for this compound when compared with respective negative controls. Thus, the present study indicates that the antimalarial compound 80/53 was not genotoxic in vivo in bone marrow cells of mice.