Chromosome Breaks and Gaps in Breast Cancer Patient
1996 年 61 巻 1 号 p. 47-51
詳細
1996 年 61 巻 1 号 p. 47-51
Chromosomal aberrations such as gaps and breaks were studied in 15 cases of breastcancers (i.e., stage II-3 cases, stage III-8 cases and stage IV-4 cases) and their 5 normal age and sex-matched controls.
The average rate of chromosome gaps and breaks were 1.61, 1.04 and 1.20 in stage II, III and IV breast cancer cases respectively, and 1.36 normal age and sex-matched control.
Chi-square comparison showed a significant difference between total breast cancer patients and normal controls (P < 0.05), a higher difference between stage II breast cancer cases and normal control (P < 0.01) and slightly higher difference between stage II and stage III breast cancer cases (P < 0.05).
The result so obtained clearly indicate that probably stage II breast cancer is a crucial stage for maximum chromosomal alteration in this malignancy.
