2001 年 66 巻 4 号 p. 395-401
The aim of this study was to investigate potential clastogenicity/genotoxicity of the antibiotic spiramycin in bone marrow cells of rats (Rattus norvegicus var. albinos). In the study, spiramycin induced the chromosome aberations at all concentrations (100, 200, 400 mg/kg bwt. (body weight) /d oral) in 21 d when compared with the solvent control group (sunflower seed oil). In addition, spiramycin induced the chromosomal aberration (CA) at only 200 mg/kg bwt. intraperitoneal (i.p.) in 12 h and 100 and 400 mg/kg bwt. i.p. in 24 h when compared with the control group. Spiramycin induced the micronucleated polichromatic erythrocytes (MNPCE) only at 200 mg/kg bwt. i.p. in 12 h and 100 mg/kg bwt. i.p. in 24 h. However, there was no significant difference in the formation of micronuclei at the other concentrations.