2010 年 20 巻 1 号 p. 27-30
Colorectal cancer (CRC) is the third most common nd cancers in the world with a very high mortality rate. In many countries like Canada and Japan it is the 2nd after lung cancer. Most CRC are sporadic, and others are familial or genetic. Sequence-time Fishbone of multistage colorectal cancer is associated between macro scopic developing [from adenomatous polyp, severe dysplasia, carcinoma, to metastasis] and up-regulated follow by mutation of several gene expression [APC, K-ras, p53, DCC] has been figured. The dancing of CD4- CD8 occur during the evolution of adenomatous polyp, severe dysplasia to carcinoma. Sequence APC, K-ras,p53, DCC gene mutation in the Fishbone has been transformed to a Firecrackers (up-regulated then down regulated APC gene will up-regulated the next gene K-ras, and p53. When K-ras and 53 is down-regulated DCC gene is up-regulated, when DCC gene is mutated metastasis happens). Non genetic, non gender, famil ial, geographical dependency (sporadic), also in young people, increase 2 to about 200 times in last decade ask many scientist who is the firelighter of the firecrackers gene mutation? The aim of this study was to identi fy the firelighter of the colorectal cancer development and progression and find that U-238 which emits alpha and beta ray during their decay is the agent.