Brentuximab vedotin. an antibody-drug conjugate targeting CD30

Abstract

Brentuximab vedotin (BV), an antibody-drug conjugate targeting CD30, is indicated for the treatment of CD30-positive relapsed/refractory Hodgkin’s lymphoma and anaplastic large cell lymphoma. When BV is internalized by CD30-positive cells, MMAE binds to microtubules to induce apoptosis. Clinically significant adverse reactions to BV include peripheral nerve disorder, infection, bone marrow suppression, and infusion reaction. The efficacy and safety of BV used in combination with other antitumor drugs have not been established. The results of multinational Phase III clinical studies of BV with chemotherapy in untreated HL and untreated CD30-positive mature T-cell lymphoma are anticipated.