抄録
After the publication of a draft sequence of the complete human genome, many biomedical projects are now in progress in view of a post-genome era. Inherited differences in DNA sequence contribute to phenotypic variation, influencing risk of many diseases and response to the environment, foods and drugs. The analysis and medical application of DNA polymorphisms, especially the single nucleotide polymorphism, are most promising among many post-genome projects. In this review, we discuss the prospects and hopes of the DNA polymorphism analysis to promote the tailor-made medicine. In the field of oncology, the prediction of the susceptibility and progression of prostate cancer may be one of the most interesting aspects of the DNA polymorphism analysis.
