抄録
New intravesical instillation therapy was performed in eleven patients with urinary fungi infection. Anti-fungal agent(HPC-Am)was made by emulsing 50 mg of amphotericin B(Am)in 15 ml hydroxypropylcellulosum(HPC). HPC-Am was given intravesically through a urethral catheter and retained for approximate an hour. A clinical relief of manifestation with absence of fugi was subsequently obtained in 9 out of 11 patients. After intravesical administration just one time, effective urinary concentration of Am against the fungi was continued for the longast period of 6 consecutive days. There was no adverse reaction of this therpy. These findings suggest that HPC-Am therapy shows more clinical effect rather than conventional Am instillation.
© 日本DDS学会