The Antinociception Produced in the Spinal Dorsal Horn by Large Myelinated Afferent Stimulation Is Mediated via Supraspinal Structures

抄録

In intact anaesthetized rats, large myelinated afferent stimulation (LMAS) produced a decrease of discharge frequency in response of spinal cord dorsal horn neurons to noxious heating. In spinalized rats, in which the cervical cord (C2-C3 segments) was transected completely, LMAS failed to reduce the neuronal discharges in response to noxious heating. This result suggests that inhibition of nociceptive responses of dorsal horn neurons produced by LMAS is mediated via descending spinal pathways from supraspinal structures.