There are many kinds of diseases in oral and maxillofacial regions, whose anatomy is very complex. Even experienced dentists cannot have appropriately decided to select the imaging modalities for the diseases in oral and maxillofacial regions. Therefore, in the present review, clinical applications in imaging modalities for many kinds of lesions in oral and maxillofacial regions are considered based on our routine examinations. In concrete, we review that the appropriate imaging modalities should be selected according to both of the regions and the suspected pathological diagnosis of diseases. At the same time, we explain that the medical interviews, visual examinations, palpations, and laboratory examinations are very important to select the appropriate imaging modalities. In particular, we precisely interpret the methods to select the appropriate modalities for the diseases in soft tissues because many dentists may be relative poor for it. In the present review, we are delight to that our methods are useful to select the appropriate imaging modalities as one of criteria for readers.