A Case of Benign Glandular Peripheral Nerve Sheath Tumor (Glandular Neurofibroma)

Abstract

We report a case of 37-year-old man with a solitary, skin colored and smooth surfaced nodule on the back. The nodule was 10 mm in diameter without symptoms. Histopathologically, the lesion was a well-circumscribed nodule in the dermis and composed of two different components. One component was a proliferation of spindle cells with an interlacing pattern, and the other was an aggregation of glandular structures. The spindle cells had variations in their nuclear sizes, but no mitotic figures. Neither pallisading nor Verocay bodies were found in the spindle cells component. There were mucin deposits positive for colloid iron staining in the lumens of the glands and in the stroma around the glands. Immunohistchemically, the spindle cells were positive for S-100, but negative for AE-1/AE-3. The glandular cells were positive for AE-1/AE-3 and synaptophysin, but negative for S-100. According to these histopathological and immunohistochemical examination, we diagnosed this case as glandular neurofibroma.