A Clinicopathological Study of Nevus Sebaceus: Relationships between Age, Location, and Histopathological Changes

Abstract

We performed a clinicopathological study of 243 cases of nevus sebaceus. Clinically, we investigated age when the lesion was resected, gender, and location of the lesion. Histopathologically, we observed the changes in the epidermis, and the presence of independent sebaceous glands without hair follicules, sebaceous glands in the papillary dermis, apocrine glands, abnormal hair follicles, and histopathological alopecia in the cases on the scalp. From those findings, we concluded that abnormal hair follicules are usually observed in infantile patients, although increases in sebaceous glands or changes in the epidermis are rare. Changes in the epidermis are often observed in childhood and increases of sebaceous glands and apocrine glands are clearly present after adolescence. It became clear that patients with similar ages do not always show similar histopathological findings.