2007 Volume 117 Issue 7 Pages 1139-1145
The usefulness of moisturizers (heparinoid preparation) for maintenance of remission in atopic dermatitis (AD) was studied in a randomized controlled trial (RCT). A total of 65 patients who applied a heparinoid preparation twice daily for two weeks to their dry skin after topical steroid treatment were randomly assigned to either the heparinoid preparation continuous application group or the untreated control group. All patients were followed up for six weeks at most. Inflammation relapsed in 12.5% of the heparinoid preparation group and 39.4% of the control group, indicating significant inhibition of inflammation relapse in the heparinoid preparation group (χ2=6.0841, p=0.0136). A significant difference was observed in the period of no inflammation between the two groups (log-rank test, p=0.0117), suggesting that continuous application of the heparinoid preparation extends the period to inflammation relapse. This study demonstrates the usefulness of moisturizers for sustained remission of AD.