Abstract
Royal jelly (RJ) is contained in health supplements, health food products, and cosmetics. We reported two cases of immediate hypersensitivity to RJ. In the skin prick test, a positive reaction was observed in response to two commercial RJ extracts in both cases. In immunoblotting, we detected bands at MW 47 kDa, 55 kDa, and 65–70 kDa. Among these proteins, no component of MW 65–70 kDa has previously been reported. From these findings, we suspect that this component may be a new and important allergen to RJ. However, this has not yet been proven by the skin prick test or the oral provocation test for the ethical problem.
