The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
Original Articles
A Case of Generalized Pustular Psoriasis Accompanied by Psoriatic Arthritis and Positive Anti-cyclic Citrullinated Peptide Antibodies
Yuhki FukunagaTsuyoshi KanbaraZenro Ikezawa
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2008 Volume 118 Issue 10 Pages 1953-1959

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Abstract

We present a case of generalized pustular psoriasis accompanied by psoriatic arthritis (PsA) which is clinically similar to rheumatoid arthritis. The patient had severe synovitis, and tests for anti-cyclic citrullinated peptide (CCP) antibodies were positive. Anti-CCP antibodies are a highly specific marker of rheumatoid arthritis, and useful in the diagnosis of the early onset of the disease. Severe arthritis with non-reversible joint destruction may develop in progressive PsA. In that case, the same treatment used for rheumatoid arthritis is recommended. We discuss whether anti-CCP antibodies are a useful barometer for treatment of PsA. The rate of positive anti-CCP antibodies in PsA is higher than in normal controls; in severe cases, it is even higher. We suggest that anti-CCP antibodies can be a prognostic factor in progressive PsA.

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© 2008 Japanese Dermatological Association
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