The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
Original Articles
A Clinicopathological Analysis of 421 Cases of Poroid cell neoplasms 4th report: Histopathological Subfindings
Keigo ItoShin-ichi AnsaiTetsunori Kimura
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2009 Volume 119 Issue 2 Pages 173-182

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Abstract

We examined 421 cases of poroid cell neoplasms. These neoplasms may show nuclear atypia and mitotic figures focally; we have called such lesions bowenoid changes, and we observed 46 cases (10.9%) with these changes. These are interpreted as benign histological findings, but we consider it a possibility that these tuncrs can develop into porocarcinoma when they are present at the periphery of the tumor. We identified 143 cases (34.0%) with necrosis en masse, 368 cases (87.4%) with nuclear grooves like coffee beans, and 236 cases (56.1%) with intranuclear vacuoles. Pale cells were present in 126 cases (29.9%) and we think that these are poroid cells with clear cytoplasm. There were 119 cases (28.3%) with pseudohorn cysts. We think that these pseudohorn cysts in the poroid cell neoplasms are formed by proliferations of tumor cells in the appendage epithelium. Poroid cell neoplasms sometimes have melanin pigment and pseudohorn cysts, so these are not definite clues for differentiation these neoplasms from seborrheic keratosis. We propose that necrosis en masse, nuclear findings, and stromal changes are clues to poroid cell neoplasms.

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© 2009 Japanese Dermatological Association
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