Outbreak of Nail Matrix Arrest Following Hand-Foot-Mouth Disease

Abstract

Beau’s lines and onycomadesis are known to result from the nail matrix arrest which is associated with drug exposures or systemic illnesses including infections. Between August and December of 2009, an outbreak of Beau’s lines and onychomadesis following hand-foot-mouth disease was observed in children and adults in Ehime, Japan. Anti-Coxackie virus A6 IgG neutralizing antibodies were positive in 10 of these patients. This is the first repot of hand-foot-mouth disease with nail matrix arrest in Japan.