2013 Volume 123 Issue 9 Pages 1807-1814
The IgE-binding epitope in red meat allergy is recently reported to be oligosaccharide galactose-α-1,3-galactose in patients residing in the U.S.A. We evaluated 20 patients with red meat allergy referred to the Department of Dermatology, Shimane University Hospital, and found that all of them had specific IgE antibodies against beef, pork, and cetuximab in their sera, indicating that the IgE reacted to oligosaccharide galactose-α-1,3-galactose. Interestingly, 15 of the 20 patients with red meat allergy also had episodes of a hypersensitivity reactions to flounder roe. Absorption experiments revealed that the flounder roe allergen has cross reactivity with the red meat allergen. Most of our patients reside in a high prevalence area of Rickettsia japonica and have a dog as a pet, although none of the patients has a previous history of Rickettsia japonica infection. Therefore, not a rickettsial infection but a tick bite, and a dog as a pet, may possibly correlate with red meat allergy in our patients, as suggested for the patients in the U.S.A.