ロドデノール誘発性脱色素斑症例における三次全国疫学調査結果

日本皮膚科学会　ロドデノール含有化粧品の安全性に関する特別委員会; 伊藤 明子; 青山 裕美; 鈴木 加余子; 鈴木 民夫; 種村 篤; 錦織 千佳子; 伊藤 雅章; 片山 一朗; 伊藤 祥輔; 大磯 直毅; 深井 和吉; 船坂 陽子; 山下 利春; 松永 佳世子

doi:10.14924/dermatol.125.2401

Committee Report

The Third Report of Epidemiology Based on a Nationwide Survey of Rhododenol-induced Leukoderma in Japan

The Special Committee on the Safety of Cosmetics Containing Rhododenol of the Japanese Dermatological Association, Akiko Ito, Yumi Aoyama, Kayoko Suzuki, Tamio Suzuki, Atsushi Tanemura, Chikako Nishigori, Masaaki Ito, Ichiro Katayama, Shosuke Ito, Naoki Oiso, Kazuyoshi Fukai, Yoko Funasaka, Toshiharu Yamashita, Kayoko Matsunaga

Author information

The Special Committee on the Safety of Cosmetics Containing Rhododenol of the Japanese Dermatological Association
Akiko Ito
Department of Dermatology, Niigata University Medical and Dental Hospital
Yumi Aoyama
Department of Dermatology, Kawasaki Medical School, Kawasaki Hospital
Kayoko Suzuki
Department of Dermatology, Kariya Toyota General Hospital
Tamio Suzuki
Department of Dermatology, Yamagata University Faculty of Medicine
Atsushi Tanemura
Department of Dermatology, Course of Integrated Medicine Graduate School of Medicine, Osaka University
Chikako Nishigori
Division of Dermatology, Department of Internal Related Graduate School of Medicine, Kobe University
Masaaki Ito
Department of Dermatology, Niigata University Graduate School of Medicine and Dental Science
Ichiro Katayama
Department of Dermatology, Course of Integrated Medicine Graduate School of Medicine, Osaka University
Shosuke Ito
Department of Chemistry, Fujita Health University School of Health Sciences
Naoki Oiso
Department of Dermatology, Kinki University Faculty of Medicine
Kazuyoshi Fukai
Department of Dermatology, Osaka City University Graduate School of Medicine
Yoko Funasaka
Department of Dermatology, Nippon Medical School
Toshiharu Yamashita
Department of Dermatology, Sapporo Medical University School of Medicine
Kayoko Matsunaga
Department of Dermatology, Fujita Health University School of Medicine

Keywords: Rhododenol, leukoderma, melanogenesis-inhibiting products, ultraviolet light irradiation

JOURNAL RESTRICTED ACCESS

2015 Volume 125 Issue 13 Pages 2401-2414

DOI https://doi.org/10.14924/dermatol.125.2401

Details

Abstract

We report the results of the third nationwide survey aimed at clarifying the clinical course of Rhododenol-induced leukoderma. The survey was performed between December 2014 and March 2015, and 981 cases were analyzed. With regard to outcome, 82% (796/964) of the cases were evaluated as improved or cured. However, 16% (156/964) of cases were evaluated as unchanged or exacerbated. In 27% (258/969) of the cases, hyperpigmentation was still observed in the affected area. 225 cases were treated with ultraviolet light irradiation that was effective in 50% of the cases. (Jpn J Dermatol 125: 2401-2414, 2015)

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