A Study of the Effects of Preemptive Interventions against Skin Disorders with Anti-EGFR Antibody

Abstract

We performed preemptive interventions against skin disorders with anti-EGFR antibody chemotherapy to treat 43 cases of colorectal cancer and head and neck cancer at the Niigata Cancer Center Hospital from November of 2011 through November 2013, and examined the effects of these interventions and the relationship between the grade of skin disorders and life prognosis. These interventions were effective in reducing the incidence rate and extending the period of the expression of the skin disorders. None of the patients discontinued chemotherapy because of the skin disorders. The skin disorder diagnoscd as grade 2 or more significantly prolonged survival in 36 colon cancer cases. We discussed the significance of preemptive interventions proactively performed by dermatologists.