The Japanese Journal of Dermatology
Online ISSN : 1346-8146
Print ISSN : 0021-499X
ISSN-L : 0021-499X
Review
Does Surgery Cure Melanoma? A Revisited Question
Minoru Takata
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2016 Volume 126 Issue 4 Pages 427-432

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Abstract

In this review article, the author discusses possible surgery-driven interruption of tumor dormancy in melanoma. He also discusses the critical appraisal of the Multicenter Selective Lymphadenectomy Trial-1 data, which reveals the low quality of the trial due to the risk of bias and imprecision of the estimated effects. Based on these considerations, the author emphasizes the importance of combining surgery with systemic therapies using a number of newly developed drugs, such as kinase inhibitors and immune check point inhibitors.

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© 2016 Japanese Dermatological Association
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