A Review of 6 Cases Developed Recall Reaction Caused by Anti-cancer Drugs

Abstract

In patients who have histories of extravasation with anticancer agents, recurrent inflammation at the site of extravasation sometimes occurs when the same drug is readministered at a different site. This reaction is referred to as "recall". We treated 6 patients who developed recall reactions despite having no obvious history of extravasation. One of these patients had a skin ulcer and required long-term treatment until it healed. Although the exact mechanism underlying the onset of the recall reaction is unclear, it may involve latent tissue damage caused by microleakage of pharmaceuticals.