2019 Volume 129 Issue 7 Pages 1497-1504
We report four cases of sporotrichosis in a 71-year-old man, a 56-year-old woman, a 68-year-old man, and a 73-year-old man. Using gene analysis in the 68 and 73 year old men, the causative organism was identified as Sporothrix globosa. In the 73-year-old patient, treatment with itraconazole was not very effective, so we switched to potassium iodide, followed by excision of all lesions. Potassium iodide was effective in the other 3 patients.
Based on genetic analysis, studies have confirmed that potassium iodide and hyperthermia are effective in Japan because the causative agent of sporotrichosis (most frequently Sporothrix globosa) does not grow at 37°C and shows low susceptibility to itraconazole.
Dermatologists should be aware of the advances in mycology, including the role of genetic testing in effectively treating mycoses.