Erythema Multiforme Following Vaccination for SARS-CoV-2: Report of a Case with the Result of Lymphocyte Transformation Test

Abstract

A 77-year-old man was referred to our department with eruptions over his entire body, which started two days after the second dose of vaccination for SARS-CoV-2 (Comirnaty^®). At the first visit three weeks after the vaccination, annular edematous erythema had spread and coalesced the trunk and extremities without itchiness; some of it presented target-like lesions. Based on the clinical and pathological findings, we diagnosed this case as erythema multiforme after the Comirnaty^® vaccination. There have been a few reports of erythema multiforme after vaccination for SARS-CoV-2, and similar cases are anticipated to emerge with the increase in the number of vaccinations and the start of a third dose for SARS-CoV-2. We here report this case with the result of lymphocytic transformation test of Comirnaty^® with healthy controls with or without vaccination and summarize the past literature reports of erythema multiforme following vaccination for SARS-CoV-2.