Dental Materials Journal
Online ISSN : 1881-1361
Print ISSN : 0287-4547
ISSN-L : 0287-4547
Non-biodegradable polymer particles for drug delivery: A new technology for “bio-active” restorative materials
Satoshi IMAZATOHaruaki KITAGAWARiriko TSUBOIRanna KITAGAWAPasiree THONGTHAIJun-ichi SASAKI
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JOURNALS FREE ACCESS Advance online publication

Article ID: 2017-156

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Abstract

To develop dental restorative materials with “bio-active” functions, addition of the capability to release active agents is an effective approach. However, such functionality needs to be attained without compromising the basic properties of the restorative materials. We have developed novel non-biodegradable polymer particles for drug delivery, aimed for application in dental resins. The particles are made using 2-hydroxyethyl methacrylate (HEMA) and a cross-linking monomer trimethylolpropane trimethacrylate (TMPT), with a hydrophilic nature to adsorb proteins or water-soluble antimicrobials. The polyHEMA/TMPT particles work as a reservoir to release fibroblast growth factor-2 (FGF-2) or cetylpyridinium chloride (CPC) in an effective manner. Application of the polyHEMA/TMPT particles loaded with FGF-2 to adhesives, or those loaded with CPC to resin-based endodontic sealers or denture bases/crowns is a promising approach to increase the success of the treatments by conferring “bio-active” properties to these materials to induce tissue regeneration or to inhibit bacterial infection.

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© 2017 The Japanese Society for Dental Materials and Devices
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