Dental Materials Journal
Online ISSN : 1881-1361
Print ISSN : 0287-4547
ISSN-L : 0287-4547
Antibacterial activity of a glass ionomer cement doped with copper nanoparticles
David AGUILAR-PEREZRossana VARGAS-CORONADOJose M. CERVANTES-UCNayeli RODRIGUEZ-FUENTESConrado APARICIOCristian COVARRUBIASMarco ALVAREZ-PEREZVictor GARCIA-PEREZMiryam MARTINEZ-HERNANDEZJuan Valerio CAUICH-RODRIGUEZ
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JOURNALS FREE ACCESS Advance online publication

Article ID: 2019-046

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Abstract

Copper nanoparticles (NCu) were synthetized and added to commercial glass ionomer cement, to evaluate in vitro its antibacterial activity against oral cavity strains. The NCu were synthesized by copper acetate reduction with L-ascorbic acid and characterized by FTIR, Raman, XPS, XRD and TEM. Then, commercial glass ionomer cement (GIC) was modified (MGIC) with various concentrations of NCu and physicochemically characterized. Cell viability was tested against human dental pulp fibroblasts (HDPFs) by Alamar-Blue assay and antibacterial test was performed against S. mutans and S. sanguinis by colony forming unit (CFU) growth method. Synthesized NCu rendered a mixture of both metallic copper and cuprous oxide (Cu2O). HDPF viability reduces with exposure time to the extracts (68–72% viability) and MGIC with 2–4 wt% NCu showed antimicrobial activity against the two tested strains.

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© 2020 The Japanese Society for Dental Materials and Devices
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