2006 Volume 15 Issue 3 Pages 73-78
This study investigated the changes of fecal flora and immune responses in dogs orally given 15 mg/kg/day chitosan-oligosaccharide. Two weeks after inoculation, the preparation had significantly increased number of fecal bifidobacteria and decreased number of fecal clostridia. Then the ratio of CD4-positive lymphocyte/CD8-positive lymphocyte was also significantly higher than those before inoculation. On other investigation, 6 weeks after inoculation, there were no the difference between inoculated groups and non-inoculated ones on serum and fecal IgA.levels There date suggested that chitosan-oligosaccharide is useful on dogs.