Amegakaryocytic Thrombocytopenia in a Dog

Abstract

A nine-year-old male Shih Tzu dog was brought to us with a two-day history of lethargy, anorexia, and vomiting. Hematological tests showed neutorophilia, anemia, and thrombocytopenia. Biochemical profile showed elevated liver enzyme, increased lipase and Spec-cPL concentrarions, and hyperglycemia. Bone marrow evaluation revealed myeloid hyperplasia, erythroid hyperplasia, and severe megakaryocytic hypoplasia. Based on these findings, the dog was diagnosed as suffering from amegakaryocytic thrombocytopenia along with pancreatitis. Supportive care and immunosuppressive treatment with vincristine and human immunoglobulin were initiated. After pancreatisis improved, prednisolone was administered. After that, platelet count increased quickly, and was in remission on day 15. The dosage of prednisolone was tapered, and discontinued on day 179. The dog has been in good condition for the past 15 months.