Journal of Animal Clinical Medicine
Online ISSN : 1881-1574
Print ISSN : 1344-6991
ISSN-L : 1344-6991
Short Report
The Combined Treatment with Topical Administration of Mitomycin C and Cryotherapy in a Dog with Suspected Dissemination of Keratoconjunctival Squamous Cell Carcinoma Followed by Surgical Resection of the Primary Conjunctival Tumor
Mizuki KITAKazutaka KANAIKimihito NOHMIKazuaki SATOYohei YAMASHITAKazuki TAJIMA
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2020 Volume 29 Issue 1 Pages 30-34


A 13-year-old female Pekingese was presented for treating a conjunctival tumor located in the left eye at the 12 o’clock position. The tumor was 4 × 4 × 1 mm in size and had a rough white-colored surface. Other ophthalmic abnormalities were present including corneal pigmentation associated with trichiasis of the left eye, bulbar conjunctival injection with corneal opacity, and bilateral vascularization. The tumor was surgically resected and identified as squamous cell carcinoma in a histopathological analysis. Two new masses were detected in the keratoconjunctival tissue of the left eye on the 14 day after surgical resection. These masses were similar to the primary tumor, and were located at the 4 o’clock and 6 to 8 o’clock positions, respectively, sites distant from the primary tumor. After cytological examination, the new tumors were suspected to be disseminated squamous cell carcinoma from the primary conjunctival tumor. The new tumors responded to the topical administration of 0.04% mitomycin C (MMC) four times per day, and the neoplastic tissue that remained was treated with cryotherapy. At the 2-month follow-up ophthalmic examination, there was no evidence of tumor recurrence, suggesting that remission had been achieved. Overall, our findings suggest that topical 0.04% MMC combined with cryotherapy may be an effective treatment for keratoconjunctival squamous cell carcinoma, particularly if surgical resection is not an option.

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© 2020 Japanese Society of Clinical Veterinary Medicin
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