DEEP OCEAN WATER RESEARCH
Online ISSN : 1884-958X
Print ISSN : 1345-8477
ISSN-L : 1345-8477
Effects of Toyama Deep Ocean Water on Cultured Human Skin Keratinocytes
Yukiko OTARie UEMATSUShintaro INOUE
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2002 Volume 3 Issue 1 Pages 15-19

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Abstract
Deep ocean water has long been known for its stable characteristics of rich mineral ingredients, a low water temperature, and chemical and bacteriological purity, but the effects of deep ocean water on skin physiology remain obscure. In this study, we examined how cultured human skin keratinocytes responded to exposure to deep ocean water from the coastal waters of Toyama Prefecture. We found that these waters promoted not only keratinocyte proliferation, but also the formation of cornified envelope in the process of keratinocyte maturation (differentiation) into cornified cells. After reviewing the mineral ingredients in the seawater, we concluded that silicate promoted this envelope formation, and that coexisting calcium accelerated the effect of the silicate. As the homeostasis of skin depends heavily on a balanced skin turnover, with finely tuned coordination between proliferation and differentiation, this deep ocean water from Toyama is expected to be useful for skin care.
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© The Deep Ocean Water Applications Society
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