We investigated the relationship between the caregiver's meal and their fatigue by an analysis with a semi-quantitative food frequency questionnaire completed by the main caregiver. The 90 caregivers were 25 men and 65 women aged 20–80 years. They took care of patients at home who required more than level 3 care or who suffered from cognitive dysfunction. Adjusted for sex and age, neither the intake of grain nor of fish and meat, which were the main food groups in respective grain meals and fish and meat meals, was significantly correlated with the caregiver's perception of fatigue. On the other hand, the correlation between caregiver's fatigue and the intake of bean and seaweed food groups was significant (p < 0.05) or non-significant (p < 0.1). Elucidation of the most appropriate type of food for the principal meal will be necessary to minimize the perception of fatigue by the caregiver.