抗生物質の給与による腸内細菌相の変化について

抄録

This paper deals with changes in the intestinal flora phase of white rats breed by a basal fodder to which a mixture five antibiotics (penicillin, streptomycin, aureomycin, chloromycetin, terramycin) and vitamin B₁₂ were added.
Antibiotics of a level of 4mg. % and 3γ% vitamin B₁₂ were added to the basal fodder.
The test animals were breed with a fodder containing either both the antiboitic mixture plus vitamin B₁₂ or each supplement separately for a period of 4 to 8 weeks, and were compared with the standard group.
Supplemnt of vitamin B₁₂ had no effect on change in the intestinal flora phase.
Lactobacilli proved to be the most effective of the control group, while this showed a distinct decrease in all animals breed with fodder containing the antibiotic mixture, coiform bacilli multiplication concurrently occuring.
No significant relationship between the change of this intestinal flora and growth of the test animals could be observed. Contrary to that mentioned above dissection revealed symptoms of abno-rmal fermentation and colitis were recognized.
There morbid symptoms seem to he due to the multiplicatin of excessive coliform bacilli, resulting from destruction of the equilibrium existing between lactobaclli and coliform bacilli.