Furylfuramide (AF-2) の幼若マウスに及ぼす影響について
カゼイン添加飼料の補足効果
1976 年 34 巻 2 号 p. 89-94
詳細
1976 年 34 巻 2 号 p. 89-94
This study was carried out to evaluate how the protein contents of the diet to modify the chemical toxicity of furylfuramide on JCL: ICR weanling mice.
The mice of basal protein groups were fed a AF-2 mixed diet containing 24% protein, and the mice of high protein groups were fed the AF-2 mixed diet containing 31% protein, enriched by casein. AF-2 concentrations in each diet were 0, 0.1 and 0.5% respectively. These AF-2 mixed diets were given ad-libitum to the weanling mice from 3 weeks to 9 weeks of age.
The results obtained are summarized as follows:
1) A slight suppression of body weight gain was observed in 0.5% AF-2 mice of basal protein groups during the course of experiment, but at 9 weeks of age, the average body weight of this group came up with the level of other groups.
2) The most remarkable finding at autopsy was the enlargement of the liver observed in AF-2 administered mice both in basal and high protein diet groups. Especially, 0.5% AF-2 mice of high protein groups showed marked liver enlargement.
3) In the histological examinations, marked degenerations of liver cells were noticed in AF-2 administered mice both in the basal and high protein diet groups.
4) In the hematological examinations, Hb and Ht decreased. and serum cholesterol increased in proportion to the concentration of AF-2 in diet both in the basal and high protein groups. As for cholesterol, the increasing rate was suppressed in the high protein groups as compared with the basal protein groups.
