高血圧自然発症ラットの血圧に及ぼすアルコールの影響
1976 年 34 巻 5 号 p. 185-189
詳細
1976 年 34 巻 5 号 p. 185-189
In this experiment, the effect of ethanol on the blood pressure was studied by using the spontaneously-hypertensive rats (SHR) developed by K. Okamoto and K. Aoki. As the experimental conditions, 31 male SHR rats aged 8 weeks were divided into three groups, i. e., a control group receiving the standard liquid diet without ethanol and two ethanol groups receiving the liquid diet containing 20% and 30% of the calories as ethanol. The experimental period was 102 days from 8 weeks to 23 weeks of age. The blood pressure was measured by tail-plethysmograph technique. The average amounts of ethanol intakes in the groups of ethanol 20 Cal. % and 30 Cal. % were 1.62 grams and 2.40 grams per day respectively.
The average blood pressure of each group was about 140mmHg at the beginning of experiment (8 weeks of age) and attained or reached to the level of 200mmHg after 8 weeks of experiment (16 weeks of age), and the significant differences of the blood pressure among three groups were not found through the whole experimental period. In the group of ethanol 20 Cal. %, the blood pressure after 9 weeks of experiment showed a slight tendency toward the lower level than other two groups. The organs of heart, liver, kidney and spleen showed neither pathological changes nor significant differences in weight among the three groups. The accumulations of liver fat were seen in ethanol groups.
