食後高脂血症と動脈硬化
2004 年 62 巻 6 号 p. 311-321
詳細
2004 年 62 巻 6 号 p. 311-321
Development in 1993 of the remnant like particle (RLP) method for conveniently measuring the serum remnant lipoprotein level prompted many studies on the atherogenic significance and metabolism of remnant lipoproteins. A novel apolipoprotein B48 receptor incorporating remnant lipoproteins into macrophages in the arterial wall was discovered, and the genetic structure of the receptor was clarified. The expression of apolipoprotein B100 was recognized in the human small intestine, suggesting that dietary very-low-density lipoproteins (VLDL) might be synthesized in the human small intestine and converted into VLDL remnants and low-density lipoproteins (LDL).
It is recognized that the atherosclerotic risk of postprandial hyperlipidemia is derived from an increase in remnant lipoproteins and that measuring the serum RLP level in the postprandial state is more sensitive and necessary for evaluating the atherosclerotic risk, because serum RLP maintains a high level all day in patients with diabetes mellitus or coronary heart disease. The relationship between postprandial hyperlipidemia and insulin resistance was clarified.
