2007 年 65 巻 5 号 p. 221-232
Lifestyle-related disease is a generic term for disease caused by the continuation of physically stressful lifestyles such as an unbalanced diet, lack of exercise, stress, smoking, and excessive drinking. In particular, the three diseases of hypertension, diabetes, and hyperlipidemia are called silent killers. They are often left untreated because of few subjective symptoms, and they become the cause of atherosclerosis, and thereby ischemic heart disease and cerebral infarction. We introduce here clinical trials that play a crucial role in secondary prevention by the early detection and treatment of lifestyle-related disease. These lifestyle-related diseases are not independent of each other. Visceral fat obesity is the cause of the disease, and the state in which a variety of diseases are likely to appear due to visceral fat obesity is called metabolic syndrome. A medical check-up on metabolic syndrome and health care instructions will become mandatory in Japan in April 2008. New developments in clinical examination such as ISO 15189, the clinical laboratory certification system, and point of care testing (POCT) are introduced.