Selective Redox Reaction of a Hydrophobic Mediator on a Self-assembled Monolayer Electrode and Its Application to a High Performance Enzyme Sensor

Abstract

Electrochemical oxidation of ascorbic acid was significantly suppressed on a 11-mercaptoundecanoic acid (MUA)-assembled gold electrode, whereas redox reaction of ferrocenylmethanol was not retarded on the same electrode. The selective oxidation reaction of the hydrophobic mediator was utilized for an amperometric glucose sensing by using a glucose oxidase-immobilized MUA electrode. It was shown that the surface-ordered electrode was useful for selective amperometric biosensing in which interference from ascorbic acid was excluded.