Electrochemistry
Online ISSN : 2186-2451
Print ISSN : 1344-3542
Articles
Hairpin DNA Unzipping Analysis Using a Biological Nanopore Array
Masayuki OHARAYusuke SEKIYARyuji KAWANO
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JOURNALS OPEN ACCESS

2016 Volume 84 Issue 5 Pages 338-341

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Abstract

This paper describes a method of hairpin DNA (hpDNA) unzipping analysis using a biological nanopore array. Various lengths of hpDNAs were captured and translocated through the nanopore and the individual duration times were monitored. The correlation between the unzipping time and the simulated hybridization energy of the duplexes was able to be modeled as first-ordered reaction. This method is one of the approach for understanding of basic biological reactions in DNA replication and RNA transcription.

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© 2016 The Electrochemical Society of Japan
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