Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
ORIGINALS
The D Allele of the Angiotensin-Converting Enzyme Insertion/Deletion (I/D) Polymorphism is a Risk Factor for Type 2 Diabetes in a Population-Based Japanese Sample
Makoto DAIMONToshihide OIZUMITamotsu SAITOHWataru KAMEDAAkihiko HIRATAHiroshi YAMAGUCHIHiroshi OHNUMAMasahiko IGARASHIMakoto TOMINAGATakeo KATO
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2003 Volume 50 Issue 4 Pages 393-398

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Abstract

The association of the ACE gene I/D polymorphism with type 2 diabetes (DM) was examined in a population-based Japanese sample. A total of 902 individuals (490 females and 412 males, age 58.8 ± 12.2 yr) from a cohort population (n = 3,706) of the Funagata diabetes study were divided into three groups according to genotype: D/D (n = 104), I/D (n = 436) and I/I (n = 362). Chi-square test and ANOVA were used for association studies and to assess the differences in the traits' values, respectively. More individuals with the genotypes D/D and I/D were diabetic (8.7% and 4.1%, respectively) than those with the genotype I/I (2.8%, p = 0.008 and p=0.032, respectively). The genotype D/D was a risk factor for DM (relative risk (RR) 3.13, 95% CI 1.31-7.51), and also for DM and IGT (RR 1.78, 95% CI 1.14-2.76). Multiple logistic regression analysis also showed that the genotypes with the D allele were risk factors for DM and IGT even when adjusting for age, sex, hypertension and serum total cholesterol levels (odds ratio 1.49, 95% CI 1.01-2.21). The D allele of the ACE gene I/D polymorphism is a risk factor for DM.

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© The Japan Endocrine Society
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