Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
Higher Serum Free Thyroxine Levels Are Associated with Coronary Artery Disease
Chan-Hee JUNGEun-Jung RHEEHun-Sub SHINSook-Kyoung JOJong-Chul WONCheol-Young PARKByung-Jin KIMKi-Chul SUNGBum-Soo KIMWon-Young LEEKi-Won OHJin-Ho KANGSung-Woo PARKMan-Ho LEESun-Woo KIM
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2008 Volume 55 Issue 5 Pages 819-826


Thyroid hormone has many effects on the heart and cardiovascular system. Thyrotoxicosis is associated with increased cardiovascular morbidity and mortality, primarily due to heart failure and thromboembolism. However, the relationship between thyroid hormone excess and the cardiac complications of angina pectoris and myocardial infarction remains largely speculative. Moreover, few studies have been reported on the effect of thyroid hormone levels within normal range on coronary artery disease (CAD). Therefore we examined the association of thyroid function with coronary artery diseases in euthyroid angina patients. Total 192 subjects (mean age; 60.8 yrs) were enrolled in which coronary angiograms were performed due to chest pain. We measured free thyroxine (FT4), thyroid stimulating hormone (TSH), serum lipid levels and high-sensitivity C-reactive protein (hsCRP) levels and analyzed their association with the presence of CAD. Serum FT4 levels were higher in patients with CAD compared with the patients without CAD (1.31 ± 0.30 vs 1.20 ± 0.23, p = 0.006), and high FT4 level was associated with the presence of multi-vessel disease. Multivariate analysis showed that age (odds ratio (OR) 1.04; 95% confidence interval (CI) 1.01-1.07, p = 0.007), hypertension (OR 2.04; 95% CI 1.06-3.90, p = 0.036) and FT4 (OR 4.23; 95% CI 1.12-15.99, p = 0.033), were the determinants for CAD. The relative risk (RR) for CAD in highest tertile of FT4 showed increased risk compared with the lowest tertile (RR 1.98; 95% CI 0.98-3.99, p<0.001). Our study showed that FT4 levels were associated with the presence and the severity of CAD. Also, this study suggests that elevated serum FT4 levels even within normal range could be a risk factor for CAD. Further studies will be necessary to confirm the relationship of thyroid function and CAD.

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