Selenium upregulates CD4+CD25+ regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2h4 mice

Haibo Xue; Weiwei Wang; Yuanbin Li; Zhongyan Shan; Yushu Li; Xiaochun Teng; Yun Gao; Chenling Fan; Weiping Teng

doi:10.1507/endocrj.K10E-063

ORIGINALS

Selenium upregulates CD4⁺CD25⁺ regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2^h4 mice

Haibo Xue, Weiwei Wang, Yuanbin Li, Zhongyan Shan, Yushu Li, Xiaochun Teng, Yun Gao, Chenling Fan, Weiping Teng

著者情報

Haibo Xue
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Department of Endocrinology and Metabolism, the Affiliated Hospital of Binzhou Medical University, Binzhou, China
Weiwei Wang
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Yuanbin Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Department of Endocrinology and Metabolism, Weihai Municipal Hospital, Weihai, China
Zhongyan Shan
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Yushu Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Xiaochun Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Yun Gao
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Chenling Fan
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China
Weiping Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, the First Affiliated Hospital, China Medical University, Shenyang, China

キーワード: Selenium, NOD.H-2^h4 mice, Autoimmune thyroiditis, Regulatory T cells

ジャーナルフリー

2010 年 57 巻 7 号 p. 595-601

DOI https://doi.org/10.1507/endocrj.K10E-063

View "Advance Publication" version (April 27, 2010).

詳細

抄録

Selenium (Se) is required for thyroid hormone synthesis and metabolism. Se treatment reduces serum thyroidspecific antibody titers in patients with autoimmune thyroiditis (AIT), but the exact mechanism is not clear. We investigated the effects of Se treatment on CD4⁺CD25⁺Foxp3⁺ regulatory T cells (Treg) in a iodine-induced autoimmune thyroiditis model. NOD.H-2^h4 mice were randomly divided into control, AIT untreated, and AIT with Se treatment groups. Mice were fed with 0.005% sodium iodine (NaI) water for 8 weeks to induce AIT. Se-treated mice received 0.3 mg/L sodium selenite in drinking water. The AIT mice had fewer Treg cells and reduced Foxp3 mRNA expression in splenocytes compared with the controls (p < 0.01). The percentage of Treg cells and expression of Foxp3 mRNA were increased by Se treatment (as compared with untreated AIT mice, p < 0.05). Mice that received Se supplementation also had lower serum thyroglobulin antibody (TgAb) titers and reduced lymphocytic infiltration in thyroids than untreated AIT mice. These data suggest that CD4⁺CD25⁺ T cells play an important role in the development of AIT. Se supplementation may restore normal levels of CD4⁺CD25⁺ T cells by up-regulating the expression of Foxp3 mRNA in mice with AIT.

責任著者(Corresponding author)

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