Fluctuation of the Plasma TRH Level in Normal Subjects in a 4-Hour Observation Period

Mizuo AZUKIZAWA; TERUNORI MITSUMA; MASAHIRO OTA; TETSURO MIKI; KIYOSHI ICHIHARA; MINORU KAWASHIMA; KIYOSHI MIYAI; YUICHI KUMAHARA

doi:10.1507/endocrj1954.27.371

Mizuo AZUKIZAWA, TERUNORI MITSUMA, MASAHIRO OTA, TETSURO MIKI, KIYOSHI ICHIHARA, MINORU KAWASHIMA, KIYOSHI MIYAI, YUICHI KUMAHARA

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ジャーナルフリー

1980 年 27 巻 3 号 p. 371-374

DOI https://doi.org/10.1507/endocrj1954.27.371

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抄録

Radioimmunoassayable TRH and TSH were measured in plasma samples taken at 5 min intervals for 4 hr (2100-0200 hr) from 4 normal male subjects. Three subjects showed a TSH surge at 2135 hr, 2455 hr and 0150 hr, respectively. The mean plasma TRH level of the 4 subjects was 10.3-11.7pg/ml. Plasma TRH showed random fluctuation, which did not coincide with the nocturnal increase in plasma TSH.

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