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Endocrinologia Japonica
Vol. 29 (1982) No. 5 P 567-573



We have examined the binding of 44% saponin from Panax ginseng, and extracts from Eleuthrococcus senticosus (Siberian ginseng) to classical steroid receptors in vitro. Both extracts had demonstrable affinity for progestin, mineralocorticoid and glucocorticoid receptors; the Siberian ginseng also bound to estrogen receptors. Highest affinity binding was to glucocorticoid receptors, with an approximate Ki of 8×10-6M for Panax ginseng. Such interactions may explain the reported glucocorticoid-like effects of ginseng in vivo.

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