Abstract
Effect of hypophysectomy on the uptake of I131 by the rat thyroid with special reference to temporal relation as well as that of methylthiouracil treatment were investigated with the following results:
The uptake of I131 by the thyroid decreased exponentially with the lapse of time after hypophysectomy. At the end of 16 weeks after the operation it decreased approximately 4.5 per cent of the control. While the change of I131 amount in the serum was not concerned with the lapse of time after hypophysectomy.
The uptake of I131 by the thyroid was decreased significantly and the I131 amount in the serum was increased by methylthiouracil administration.
