Endocrinologia Japonica
Online ISSN : 2185-6370
Print ISSN : 0013-7219
ISSN-L : 0013-7219
Effect of Intracerebroventricular Administration of Rat Calcitonin Gene-Related Peptide (CGRP), Human Calcitonin and [Asu1, 7]-Eel Calcitonin on Gastric Acid Secretion in Rats
YASUHIKO OKIMURAKAZUO CHIHARAHIROMI ABEHIDESUKE KAJITETSUYA KITAYOICHI KASHIOTAKUO FUJITA
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1986 Volume 33 Issue 2 Pages 273-277

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Abstract

The effect of intracerebroventricular injection of rat calcitonin gene-related peptide (CGRP), human calcitonin (CT) and [Asu1, 7]-eel CT on the volume and acidity of gastric juice was examined in the pylorus-ligated male rats. These 3 peptides were effective in suppressing both the volume and acidity of secreted gastric juice. Their potency on a molar basis, however, was markedly different;[Asu1, 7]-eel CT was most potent, followed by human CT and finally by rat CGRP. These finding suggest that CGRP could not substitute for [Asu1, 7]-eel or human CT in exerting the suppressive effect of gastric acid secretion.

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© The Japan Endocrine Society
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