Effects of Corticotropin-Releasing Factor (CRF) on Aldosterone and 18-Hydroxycorticosterone in Essential Hypertension and Primary Aldosteronism

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The effects of ovine corticotropin releasing factor (o-CRF) on plasma aldosterone, 18-OH-corticosterone (18-OHB), plasma adrenocorticotropin (ACTH) and cortisol were determined in eight patients with primary aldosteronism, six with aldosterone-producing adenoma (APA) and two with idiopathic hyperaldosteronism (IHA). The results were compared with those in six normal subjects and eleven patients with essential hypertension (EHT, 5with low renin and 6 with normal renin). In patients with APA, the peak plasma aldosterone and 18-OHB responses to 100μg iv of o-CRF (226%and 113% increase from baseline, respectively) were greater than those in EHT and normal subjects. The net integrated aldosterone and 18-OHB responses (840±156, and 419±121 ng/dl·hr, respectively) were also significantly greater (P<0.01) in APA than those in normals and EHT. In two patients with IHA, both the peak and net integrated aldosterone response were smaller than those in APA, in spite of nearly identical plasma ACTH and cortisol responses. These results suggest that augmented responses of mineralocorticoids to o-CRF may be characteristic of aldosteronism due to APA, mediated by CRF. induced ACTH, and possibly other proopiomelanocortin (POMC)-derived peptides.