抄録
The effects of bile salts on the release of immunoreactive vasoactive intestinal polypeptide (IR-VIP) were investigated in men using a specific radioimmunoassay. Plasma IR-VIP was determined after extraction by the acidacetone method (recovery 75±5%). Oral administration of 400 mg sodium taurocholate caused a rise in plasma IR-VIP from 18.5±1.3pmol/l to 31.1±2.1 pmol/l after 30min and 39.0±1.7pmol/l after 60min and return to the initial value after 120min. Oral administration of chenodeoxycholic acid (CDCA) also increased plasma IR-VIP from a basal level of 14.5±1.5 pmol/l to 36.3±1.2 pmol/l after 60min. Oral administration of ursodeoxycholic acid (UDCA) increased plasma IR-VIP from 11.9±1.1 pmol/l to 25.6±1.8 pmol/l after 30min. Perifusion of 1m M taurocholate stimulated release of IR-VIP from human duodenal mucosa into the perifusate.
These results suggest that bile salts may participate, at least in part, in the release of IR-VIP from the gut.
