Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
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Subcapsular Cell Hyperplasia and Mast Cell Infiltration in the Adrenal Cortex of Mice: Comparative Study in 7 Inbred Strains
Jong-Soo KIMHisayo KUBOTAYoshihiro KIUCHIKunio DOIJunzo SAEGUSA
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1997 年 46 巻 4 号 p. 303-306

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Subcapsular cell hyperplasia (SCH) in the adrenal cortex of aged mice (13-15 months old) was frequent in both sexes of BALB/c, C3H/He, DBA/2J and IQI/Jic mice and in the females of A/J and C57BL/6, although the incidence and severity of SCH were considerably different among mouse strains. Mast cells were closely associated with SCH in the A/J, BALB/c, C57BL/6, DBA/2J and IQI/Jic mice, but not in the C3H/He strain. Compared with other strains, IQI/Jic mice had a significantly larger number of mast cells in the adrenal glands. Our findings suggest that mast cells may participate in the development of SCH, and IQI/Jic would be suitable for studying the pathogenesis of SCH and the role of mast cells in this lesion.

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© 1997 Japanese Association for Laboratory Animal Science
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