Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Note
Replication of Murine Coronaviruses in Mouse Embryonic Stem Cell Lines in vitro
Shigeru KYUWA
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ジャーナル フリー

1997 年 46 巻 4 号 p. 311-313

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Replication of murine coronaviruses in eight mouse embryonic stem (ES) cell lines of several genetic backgrounds was examined. Both mouse hepatitis virus (MHV) type 2 and MHV, strain A59 replicated well with no or minimal cytopathic effect in all the ES cell lines tested. The results suggest the possibility that MHV-infected ES cells may disseminate MHV in mouse colonies due to embryo manipulation.

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© 1997 Japanese Association for Laboratory Animal Science
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