Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Note
A Genetic Linkage Map of Rat Chromosome 9 with a New Locus for Variant Activity of Liver Aldehyde Oxidase
Tetsuo KUNIEDAEiji KOBAYASHIMotokazu TACHIBANAHiroshi IKADAI
著者情報
キーワード: Aox, linkage map, rat
ジャーナル フリー

1999 年 48 巻 1 号 p. 43-45

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抄録

A genetic linkage map of rat chromosome 9 consisting of five loci including a new biochemical marker representing a genetic variation of the activity of the liver aldehyde oxidase, (Aox) was constructed. Linkage analysis of the five loci among 92 backcross progeny of (WKS/Iar × IS/Iar)F1 × WKS/Iar revealed significant linkages between these loci. Minimizing crossover frequency resulted in the best gene order: Aox-D9Mit4-Gls-Cryg-Tp53l1. The homologues of the Cryg, Gls, and Aox genes have been mapped on mouse chromosome 1 and human chromosome 2q. The present findings provide further evidence for the conservation of synteny among these regions of rat, mouse, and human chromosomes.

著者関連情報
© 1999 Japanese Association for Laboratory Animal Science
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